Brain Ischemia

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22. Liu RR, Murphy TH. Reversible cyclosporin A-sensitive mitochondrial depolarization occurs within minutes of stroke onset in mouse somatosensory cortex in vivo: a two-photon imaging study. J Biol Chem. 2009 Dec 25;284(52):36109-17.

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24. Matsumoto S, Friberg H, Ferrand-Drake M, Wieloch T. Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab. 1999 Jul;19(7):736-41.

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40. Shiga Y, Onodera H, Matsuo Y, Kogure K. Cyclosporin A protects against ischemia-reperfusion injury in the brain. Brain Res. 1992 Nov 6;595(1):145-8.

41. Siesjo BK, Elmer E, Janelidze S, Keep M, Kristian T, Ouyang YB, et al. Role and mechanisms of secondary mitochondrial failure. Acta Neurochir Suppl. 1999;73:7-13.

42. Sinigaglia-Coimbra R, Cavalheiro EA, Coimbra C. Protective effect of systemic treatment with cyclosporine A after global ischemia in rats. J Neurol Sci. 2002 Nov 15;203-204:273-6.

43. Tachibana T, Shiiya N, Kunihara T, Wakamatsu Y, Kudo AF, Ooka T, et al. Immunophilin ligands FK506 and cyclosporine A improve neurologic and histopathologic outcome after transient spinal cord ischemia in rabbits. J Thorac Cardiovasc Surg. 2005 Jan;129(1):123-8.

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45. Uchino H, Elmer E, Uchino K, Li PA, He QP, Smith ML, et al. Amelioration by cyclosporin A of brain damage in transient forebrain ischemia in the rat. Brain Res. 1998 Nov 23;812(1-2):216-26.

46. Uchino H, Elmer E, Uchino K, Lindvall O, Siesjo BK. Cyclosporin A dramatically ameliorates CA1 hippocampal damage following transient forebrain ischaemia in the rat. Acta Physiol Scand. 1995 Dec;155(4):469-71.

47. Uchino H, Ishii N, Shibasaki F. Calcineurin and cyclophilin D are differential targets of neuroprotection by immunosuppressants CsA and FK506 in ischemic brain damage. Acta Neurochir Suppl. 2003;86:105-11.

48. Uchino H, Minamikawa-Tachino R, Kristian T, Perkins G, Narazaki M, Siesjo BK, et al. Differential neuroprotection by cyclosporin A and FK506 following ischemia corresponds with differing abilities to inhibit calcineurin and the mitochondrial permeability transition. Neurobiol Dis. 2002 Aug;10(3):219-33.

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51. Waldmeier PC, Zimmermann K, Qian T, Tintelnot-Blomley M, Lemasters JJ. Cyclophilin D as a drug target. Curr Med Chem. 2003 Aug;10(16):1485-506.

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53. Yagita Y, Kitagawa K, Matsushita K, Taguchi A, Mabuchi T, Ohtsuki T, et al. Effect of immunosuppressant FK506 on ischemia-induced degeneration of hippocampal neurons in gerbils. Life Sci. 1996;59(19):1643-50.

54. Yamaguchi T, Miyata K, Shibasaki F, Isshiki A, Uchino H. Effect of cyclosporin a on immediate early gene in rat global ischemia and its neuroprotection. J Pharmacol Sci. 2006 Jan;100(1):73-81.

55. Yoshimoto T, Siesjo BK. Posttreatment with the immunosuppressant cyclosporin A in transient focal ischemia. Brain Res. 1999 Aug 28;839(2):283-91.

56. Yoshimoto T, Uchino H, He QP, Li PA, Siesjo BK. Cyclosporin A, but not FK506, prevents the downregulation of phosphorylated Akt after transient focal ischemia in the rat. Brain Res. 2001 Apr 27;899(1-2):148-58.

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58. Zaidan E, Nilsson M, Sims NR. Cyclosporin A-sensitive changes in mitochondrial glutathione are an early response to intrastiatal NMDA or forebrain ischemia in rats. J Neurochem. 1999 Nov;73(5):2214-7.

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Eleonor Åsander Frostner

Responsible editor Eleonor Åsander Frostner Last updated: 2012-05-23