Interim Report January-September 2020
Primary mitochondrial disorders are either caused by genetic changes in mitochondrial DNA or mutations in nuclear DNA. The precise incidence of these mitochondrial disorders is unknown, and many individuals with mitochondrial disease have not been diagnosed. As a group, mitochondrial disorders are one of the most common hereditary illnesses cited in international medical literature, with an estimated 12 people in every 100,000 having a primary mitochondrial disorder.
TBI is one of the most common causes of death and disability in children and young people worldwide. In TBI, nerve cells are damaged immediately. The damage then continues to exacerbate several days after the initial trauma, which often has a significant effect on the extent of the injury.
Non-alcoholic steatohepatitis (NASH) involves fat incorporation in the liver in combination with inflammation. The condition may develop into liver cirrhosis or hepatocellular cancer (HCC). There is a strong association between NASH and a variety of metabolic syndromes like diabetes and obesity. Approximately 3-5% of Americans (approx. 15 million people) suffer from NASH and there are currently no registered drugs for the treatment of this condition.
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